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KMID : 0369820170470060461
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Jorunal of Korean Pharmaceutical Sciences
2017 Volume.47 No. 6 p.461 ~ p.473
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Solid matrix-based lipid nanoplatforms as carriers for combinational therapeutics in cancer
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Gupta Biki
Yong Chul-Soon
Kim Jong-Oh
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Abstract
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Combination therapy, which targets different mechanisms responsible for tumor development and proliferation, has become the norm for modern cancer treatment. The basic purpose for combining treatment agents or modalities varies between obtaining synergistic anticancer effects, reducing the toxic effects of the treatment agents, and suppressing multidrug resistant variants of cancer cells. Nanoscale therapeutic carriers enhance the accessibility of combination agents to cancer sites, prevent non-specific accumulation of therapeutic agents in peripheral organs, and help control and direct the amount and rate of release of therapeutic agents at tumoral sites. Solid matrix-based lipid nanoparticles, comprised of solid lipid nanoparticles and nanostructured lipid carriers, have recently been popular for delivering various therapeutic agents, including diverse combinations, to cancer cells. Because of their incredible physicochemical characteristics, ability to incorporate diverse therapeutic agents, and ability to modify nanoparticle surfaces with targeting ligands or other diagnostic and therapeutic agents, solid matrix-based lipid nanoparticles have been widely reported for co-delivery of various chemotherapeutic drug combinations, including chemotherapeutic drugs and genetic materials, chemotherapeutic drugs and immunotherapeutic agents, chemotherapeutic drugs and therapeutic peptides, and other miscellaneous agents. Thus, the immense potential for efficient delivery of these agents to achieve effective cancer therapy is illustrated.
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KEYWORD
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Solid matrix, Combination cancer therapy, Nanostructured lipid carriers, Solid lipid nanoparticles
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